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KMID : 0391520150230030099
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Journal of the Korean Child Neurology Society
2015 Volume.23 No. 3 p.99 ~ p.103
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Clinical Characteristics of Influenza-associated Seizure in Children
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Park Young-Mi
Lee Hyo-Eun
Kim Seung-Yeon
Kim Hyun-Jung
Kang Ju-Hyung
Lee Soo-Jin
You Chur-Woo
Kim Jon-Soo
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Abstract
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Purpose: Seizures are the most frequently reported neurologic complication during an influenza epidemic. Even older than 5 years, influenza-associated seizure increases significantly in children. This study sought to better understand the risks and outcomes of seizures associated with epidemic influenza in the pediatric population.
Method: We retrospectively reviewed the medical charts of children with laboratoryconfirmed influenza between December 2013 and April 2015. Data analyzed included patient’s demographics, clinical presentation, radiological and electroencephalographic findings, management and prognosis.
Results: A total of 290 children (male 168, female 122) were identified as having laboratory-confirmed influenza A (211 of 290; 72.8%) or B (79 of 290; 27.2%). The mean age was 4.6 years (range, 0.1-17.2 years). Among them, 30 (10.3%) patients had seizures at a median age 4.8 years (range, 0.7-15.0 years), including 10 (33.3%) patients older than 5 years. All patients had fever and 17 (56.7%) patients had history of febrile seizure. Mostly, they showed generalized seizure (25 of 30; 83.3%) and prolonged seizure of less than 5 minutes (28 of 30; 93.3%). Sixteen (53.3%) underwent Electroencephalogram (EEG) and revealed normal finding in all patients. Brain Magnetic resonance imaging(MRI) was
performed in 5 (16.7%) patients without abnormality. Four patients (13.3%) had more seizures during febrile illness but no need to treat with intravenous antiepileptic drugs. All patients discharged to home without complication.
Conclusion: Although most patients with influenza-associated seizure had benign clinical course, we should be aware of occurrence in all age group of childhood as well as beyond the typical age at which febrile seizures.
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KEYWORD
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Influenza, Influenza A virus, Seizures, Child
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